Copper Tripeptide
What is GHK-Cu?
GHK-Cu (glycyl-L-histidyl-L-lysine:copper) is a naturally occurring human plasma tripeptide that forms a stable complex with copper(II) ions. It was first isolated in 1973 and has since been extensively studied for its roles in wound healing, tissue remodelling, anti-inflammatory signalling, and skin biology.
Mechanism of Action
GHK-Cu activates a wide range of biological pathways. It stimulates collagen and glycosaminoglycan synthesis, promotes angiogenesis, modulates the activity of matrix metalloproteinases (MMPs), and exhibits antioxidant activity. Research also indicates it can regulate over 4,000 human genes, influencing both pro-regenerative and anti-inflammatory pathways.
Wound Healing Research
GHK-Cu has been studied extensively for accelerating wound closure and improving skin repair quality. Preclinical data suggests it promotes fibroblast proliferation, enhances extracellular matrix production, and reduces post-wound contraction, resulting in superior tissue architecture.
Skin Biology Applications
In dermatological research, GHK-Cu is associated with reduced skin laxity, improved skin density, stimulation of hair follicle growth, and reduction in fine lines. Its ability to activate TGF-β pathways makes it of interest in anti-ageing skin research.
Storage & Handling
GHK-Cu is relatively stable. Store lyophilised powder at 2–8°C, away from light and moisture. Once in solution, store at −20°C if not used within 24–48 hours.
Research Disclaimer: GHK-Cu is a research compound. It has not been approved for therapeutic use by any regulatory body. All information is for educational and scientific research purposes only.